# Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock

> **NCT03953677** · PHASE3 · TERMINATED · sponsor: **Centre Hospitalier Universitaire Dijon** · enrollment: 32 (actual)

## Conditions studied

- Septic Shock
- Vasopressor Resistance

## Interventions

- **DRUG:** Dexmedetomidine 100 Mcg/mL Intravenous Solution
- **DRUG:** 5% glucose Infusion solution

## Key facts

- **NCT ID:** NCT03953677
- **Lead sponsor:** Centre Hospitalier Universitaire Dijon
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-10-27
- **Primary completion:** 2023-01-31
- **Final completion:** 2023-03-22
- **Target enrollment:** 32 (ACTUAL)
- **Why stopped:** Excess mortality in one arm of the study that led to discontinuation of enrollment
- **Last updated:** 2026-02-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03953677

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03953677, "Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT03953677. Licensed CC0.

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