# Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

> **NCT03970096** · PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 120 (estimated)

## Conditions studied

- Acute Leukemia
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Myelodysplastic Syndrome
- Myeloproliferative Neoplasm

## Interventions

- **RADIATION:** Total-Body Irradiation
- **DRUG:** Thiotepa
- **DRUG:** Fludarabine
- **DRUG:** Tacrolimus
- **BIOLOGICAL:** Allogeneic CD34+-enriched and CD45RA-depleted PBSCs
- **DRUG:** Methotrexate
- **DRUG:** Cyclophosphamide
- **BIOLOGICAL:** Peripheral Blood Stem Cell
- **DRUG:** Cyclosporine
- **DRUG:** Sirolimus
- **DRUG:** Busulfan
- **PROCEDURE:** Bone Marrow Aspiration and Biopsy
- **PROCEDURE:** Echocardiography
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT03970096
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-11-19
- **Primary completion:** 2027-12-31
- **Final completion:** 2029-12-31
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-03-12

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03970096

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03970096, "Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03970096. Licensed CC0.

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