# A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

> **NCT03970447** · PHASE2,PHASE3 · RECRUITING · sponsor: **Global Coalition for Adaptive Research** · enrollment: 2250 (estimated)

## Conditions studied

- Glioblastoma

## Interventions

- **DRUG:** Temozolomide
- **DRUG:** Lomustine
- **DRUG:** Regorafenib
- **RADIATION:** Radiation
- **DRUG:** Paxalisib
- **DRUG:** VAL-083
- **DRUG:** VT1021
- **DRUG:** Troriluzole
- **BIOLOGICAL:** ADI-PEG 20
- **DRUG:** AZD1390
- **DRUG:** Tinostamustine

## Key facts

- **NCT ID:** NCT03970447
- **Lead sponsor:** Global Coalition for Adaptive Research
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-07-30
- **Primary completion:** 2028-06
- **Final completion:** 2030-06
- **Target enrollment:** 2250 (ESTIMATED)
- **Last updated:** 2026-05-15

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03970447

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03970447, "A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma". Retrieved via AI Analytics 2026-08-13 from https://api.ai-analytics.org/clinical/NCT03970447. Licensed CC0.

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