# Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

> **NCT03973268** · PHASE1 · RECRUITING · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 70 (estimated)

## Conditions studied

- Depression
- Major Depressive Disorder
- Major Depression

## Interventions

- **DEVICE:** Arm 1, 2, 3 device interventions
- **OTHER:** Arm 2 Interventions
- **DRUG:** Arm 1, 2, 3 drug Interventions
- **DRUG:** Arm 1 and 2 Interventions

## Key facts

- **NCT ID:** NCT03973268
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-01-21
- **Primary completion:** 2027-02-01
- **Final completion:** 2027-02-01
- **Target enrollment:** 70 (ESTIMATED)
- **Last updated:** 2026-02-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03973268

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03973268, "Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression". Retrieved via AI Analytics 2026-07-03 from https://api.ai-analytics.org/clinical/NCT03973268. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*