# Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen

> **NCT03974932** · PHASE3 · COMPLETED · sponsor: **Heron Therapeutics** · enrollment: 116 (actual)

## Conditions studied

- Analgesia

## Interventions

- **DRUG:** HTX-011
- **DRUG:** Ibuprofen
- **DRUG:** Acetaminophen
- **DRUG:** Celecoxib
- **DRUG:** +/- Bupivacaine HCl
- **DEVICE:** Luer Lock Applicator
- **DRUG:** HTX-011

## Key facts

- **NCT ID:** NCT03974932
- **Lead sponsor:** Heron Therapeutics
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-06-05
- **Primary completion:** 2020-12-07
- **Final completion:** 2021-01-07
- **Target enrollment:** 116 (ACTUAL)
- **Last updated:** 2026-03-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03974932

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03974932, "Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT03974932. Licensed CC0.

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