# Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV

> **NCT03976258** · — · COMPLETED · sponsor: **MetroHealth Medical Center** · enrollment: 190 (actual)

## Conditions studied

- HIV Infection
- Opioid-use Disorder
- Cardiovascular Diseases

## Interventions

- **DRUG:** buprenorphine/naloxone
- **DRUG:** Methadone
- **DRUG:** Naltrexone Injection
- **DRUG:** Heroin

## Key facts

- **NCT ID:** NCT03976258
- **Lead sponsor:** MetroHealth Medical Center
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2017-07-14
- **Primary completion:** 2022-12-31
- **Final completion:** 2022-12-31
- **Target enrollment:** 190 (ACTUAL)
- **Last updated:** 2023-10-02

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03976258

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03976258, "Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT03976258. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*