# Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients

> **NCT03976544** · PHASE4 · TERMINATED · sponsor: **CRG UZ Brussel** · enrollment: 362 (actual)

## Conditions studied

- Miscarriage
- Frozen Embryo Transfer
- Natural Cycle
- Hormone Replacement Therapy Cycle
- Preimplantation Genetic Screening
- Euploid Embryos

## Interventions

- **DRUG:** Estradiol Valerate
- **DRUG:** Micronized progesterone

## Key facts

- **NCT ID:** NCT03976544
- **Lead sponsor:** CRG UZ Brussel
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-05-25
- **Primary completion:** 2025-01-01
- **Final completion:** 2025-01-01
- **Target enrollment:** 362 (ACTUAL)
- **Why stopped:** safety
- **Last updated:** 2025-01-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03976544

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03976544, "Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03976544. Licensed CC0.

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