# Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit

> **NCT04004091** · EARLY_PHASE1 · COMPLETED · sponsor: **dr. Riana Pauline Tamba, SpB(K)BA** · enrollment: 42 (actual)

## Conditions studied

- Premature Birth
- NEC

## Interventions

- **BIOLOGICAL:** Spermine

## Key facts

- **NCT ID:** NCT04004091
- **Lead sponsor:** dr. Riana Pauline Tamba, SpB(K)BA
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-03-01
- **Primary completion:** 2019-09-30
- **Final completion:** 2019-09-30
- **Target enrollment:** 42 (ACTUAL)
- **Last updated:** 2020-03-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04004091

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04004091, "Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04004091. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*