# Closed-Loop Deep Brain Stimulation for Major Depression

> **NCT04004169** · NA · RECRUITING · sponsor: **Andrew Krystal** · enrollment: 12 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DEVICE:** Stimulation-ON
- **DEVICE:** Stimulation-OFF
- **DEVICE:** Stimulation-ON Active Control

## Key facts

- **NCT ID:** NCT04004169
- **Lead sponsor:** Andrew Krystal
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-07-18
- **Primary completion:** 2030-06-28
- **Final completion:** 2035-06-28
- **Target enrollment:** 12 (ESTIMATED)
- **Last updated:** 2023-05-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04004169

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04004169, "Closed-Loop Deep Brain Stimulation for Major Depression". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04004169. Licensed CC0.

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