# A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies

> **NCT04020198** · — · TERMINATED · sponsor: **Stony Brook University** · enrollment: 8 (actual)

## Conditions studied

- Parkinson Disease
- Multiple System Atrophy
- Rapid Eye Movement Sleep Behavior Disorder
- Normal Pressure Hydrocephalus

## Interventions

- **OTHER:** Biomarker assay

## Key facts

- **NCT ID:** NCT04020198
- **Lead sponsor:** Stony Brook University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** TERMINATED
- **Start date:** 2020-01-15
- **Primary completion:** 2022-10-19
- **Final completion:** 2022-10-19
- **Target enrollment:** 8 (ACTUAL)
- **Why stopped:** The assay under investigation did not show evidence of accurately detecting alpha-synuclein in specimens collected in the study other than CSF and the intention of the study was to identify less invasive ways to measure alpha-synuclein.
- **Last updated:** 2025-04-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04020198

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04020198, "A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT04020198. Licensed CC0.

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