Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors

NCT04023669 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

21

Enrollment

OTHER

Sponsor class

Conditions

Brain Tumor
Brain Tumor, Recurrent
Brain Tumor, Refractory
Brain Tumor, Pediatric
Medulloblastoma
Medulloblastoma Recurrent
Medulloblastoma, Non-WNT/Non-SHH
Medulloblastoma, Non-WNT/Non-SHH, Group 3
Medulloblastoma, Non-WNT/Non-SHH, Group 4
Brain Cancer
CNS Cancer
CNS Tumor
CNS Neoplasm

Interventions

DRUG: Prexasertib
DRUG: Cyclophosphamide
DRUG: Gemcitabine
BIOLOGICAL: filgrastim
BIOLOGICAL: peg-filgrastim

Sponsor

St. Jude Children's Research Hospital

Collaborators

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