# Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women

> **NCT04037605** · EARLY_PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center** · enrollment: 5 (actual)

## Conditions studied

- Sleep Restriction

## Interventions

- **DRUG:** Ketoconazole Pill (also known as nizoral)
- **DRUG:** Ganirelix
- **DRUG:** Dexamethasone Pill
- **DRUG:** Dexamethasone injection
- **DRUG:** Cosyntropin Injectable Product
- **DRUG:** Recombinant Human Luteinizing Hormone (also known as luveris)
- **DRUG:** Hydrocortisone Injection (also known as solu-cortef)
- **DRUG:** Gonadorelin (also known as Lutrepulse)
- **DRUG:** Corticorelin (also known as Acthrel)
- **DRUG:** Placebo oral tablet
- **DRUG:** Saline Solution
- **DRUG:** Saline solution for injection

## Key facts

- **NCT ID:** NCT04037605
- **Lead sponsor:** Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-02-09
- **Primary completion:** 2022-07-24
- **Final completion:** 2026-06-24
- **Target enrollment:** 5 (ACTUAL)
- **Last updated:** 2025-09-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04037605

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04037605, "Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04037605. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*