# Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer

> **NCT04044430** · PHASE1 · TERMINATED · sponsor: **University of California, San Francisco** · enrollment: 2 (actual)

## Conditions studied

- Metastatic Colon Adenocarcinoma
- Metastatic Colorectal Adenocarcinoma
- Metastatic Microsatellite Stable Colorectal Carcinoma
- Metastatic Rectal Adenocarcinoma
- Stage III Colon Cancer
- Stage III Colorectal Cancer
- Stage III Rectal Cancer
- Stage IIIA Colon Cancer
- Stage IIIA Colorectal Cancer
- Stage IIIA Rectal Cancer
- Stage IIIB Colon Cancer
- Stage IIIB Colorectal Cancer
- Stage IIIB Rectal Cancer
- Stage IIIC Colon Cancer
- Stage IIIC Colorectal Cancer
- Stage IIIC Rectal Cancer
- Stage IV Colon Cancer
- Stage IV Colorectal Cancer
- Stage IV Rectal Cancer
- Stage IVA Colon Cancer
- Stage IVA Colorectal Cancer
- Stage IVA Rectal Cancer
- Stage IVB Colon Cancer
- Stage IVB Colorectal Cancer
- Stage IVB Rectal Cancer
- Stage IVC Colon Cancer
- Stage IVC Colorectal Cancer
- Stage IVC Rectal Cancer

## Interventions

- **DRUG:** Binimetinib
- **DRUG:** Encorafenib
- **BIOLOGICAL:** Nivolumab
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT04044430
- **Lead sponsor:** University of California, San Francisco
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2020-08-31
- **Primary completion:** 2022-07-31
- **Final completion:** 2022-07-31
- **Target enrollment:** 2 (ACTUAL)
- **Why stopped:** Sponsor funding
- **Last updated:** 2023-01-09

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04044430

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04044430, "Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT04044430. Licensed CC0.

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