# Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

> **NCT04049786** · PHASE4 · UNKNOWN · sponsor: **Natalia Valadares de Moraes** · enrollment: 120 (estimated)

## Conditions studied

- Obesity
- Bariatric Surgery
- Roux-en Y Gastric Bypass

## Interventions

- **PROCEDURE:** Digestive biopsy
- **DRUG:** Carvedilol 25mg
- **PROCEDURE:** Serial blood sampling for PK analysis
- **DRUG:** Metoprolol 100 mg for CYP2D6 phenotyping
- **DRUG:** Simvastatin 40mg
- **DRUG:** Midazolam 2 mg for CYP3A4 phenotyping
- **OTHER:** Genotyping

## Key facts

- **NCT ID:** NCT04049786
- **Lead sponsor:** Natalia Valadares de Moraes
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2019-06-01
- **Primary completion:** 2022-08
- **Final completion:** 2023-08
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2022-02-08

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04049786

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04049786, "Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol". Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/clinical/NCT04049786. Licensed CC0.

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