# Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)

> **NCT04069312** · PHASE4 · COMPLETED · sponsor: **Johns Hopkins University** · enrollment: 1032 (actual)

## Conditions studied

- Chronic Obstructive Pulmonary Disease Severe
- Chronic Bronchitis

## Interventions

- **DRUG:** Roflumilast
- **DRUG:** Azithromycin

## Key facts

- **NCT ID:** NCT04069312
- **Lead sponsor:** Johns Hopkins University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-02-11
- **Primary completion:** 2026-03-01
- **Final completion:** 2026-03-01
- **Target enrollment:** 1032 (ACTUAL)
- **Last updated:** 2026-03-06

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04069312

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04069312, "Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT04069312. Licensed CC0.

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