# Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects

> **NCT04080895** · PHASE1 · TERMINATED · sponsor: **University of Oxford** · enrollment: 8 (actual)

## Conditions studied

- Pharmacokinetic
- Healthy
- Drug Combination

## Interventions

- **DRUG:** Artemether-lumefantrine
- **DRUG:** Amodiaquine
- **DRUG:** Artemether-lumefantrine
- **DRUG:** Artemether-lumefantrine + Amodiaquine

## Key facts

- **NCT ID:** NCT04080895
- **Lead sponsor:** University of Oxford
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-11-01
- **Primary completion:** 2025-04-01
- **Final completion:** 2025-04-01
- **Target enrollment:** 8 (ACTUAL)
- **Why stopped:** The decision was made due to the expired investigational drug and regulatory changes by the Thai FDA, along with increased importation costs. The research team and investigational drug sponsor agreed to seek approval for early project termination.
- **Last updated:** 2026-01-12

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04080895

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04080895, "Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT04080895. Licensed CC0.

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