# A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma

> **NCT04111172** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Thomas Jefferson University** · enrollment: 48 (actual)

## Conditions studied

- Pancreatic Ductal Adenocarcinoma
- Colorectal Adenocarcinoma
- Gastric Adenocarcinoma
- Clinical Stage II Gastric Cancer AJCC v8
- Clinical Stage IIA Gastric Cancer AJCC v8
- Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8
- Clinical Stage IIB Gastric Cancer AJCC v8
- Clinical Stage III Esophageal Adenocarcinoma AJCC v8
- Clinical Stage III Gastric Cancer AJCC v8
- Malignant Solid Neoplasm
- Pathologic Stage II Gastric Cancer AJCC v8
- Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8
- Pathologic Stage IIB Gastric Cancer AJCC v8
- Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
- Pathologic Stage III Gastric Cancer AJCC v8
- Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
- Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
- Pathologic Stage IIIA Gastric Cancer AJCC v8
- Pathologic Stage IIIB Gastric Cancer AJCC v8
- Pathologic Stage IIIC Gastric Cancer AJCC v8
- Stage I Pancreatic Cancer AJCC v8
- Stage IA Pancreatic Cancer AJCC v8
- Stage IB Pancreatic Cancer AJCC v8
- Stage II Pancreatic Cancer AJCC v8
- Stage IIA Pancreatic Cancer AJCC v8
- Stage IIB Pancreatic Cancer AJCC v8
- Stage III Colorectal Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IIIA Colorectal Cancer AJCC v8
- Stage IIIB Colorectal Cancer AJCC v8
- Stage IIIC Colorectal Cancer AJCC v8
- Stage IV Colorectal Cancer AJCC v8
- Stage IVA Colorectal Cancer AJCC v8
- Stage IVB Colorectal Cancer AJCC v8
- Malignant Digestive System Neoplasm
- Small Intestinal Adenocarcinoma
- Stage III Small Intestinal Adenocarcinoma AJCC v8
- Stage IIIA Small Intestinal Adenocarcinoma AJCC v8

## Interventions

- **BIOLOGICAL:** Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE

## Key facts

- **NCT ID:** NCT04111172
- **Lead sponsor:** Thomas Jefferson University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-11-10
- **Primary completion:** 2026-03-01
- **Final completion:** 2027-03-01
- **Target enrollment:** 48 (ACTUAL)
- **Last updated:** 2025-08-22


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04111172

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04111172, "A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT04111172. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*