# Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

> **NCT04142177** · NA · RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 2529 (estimated)

## Conditions studied

- Chronic Low Back Pain

## Interventions

- **OTHER:** Pain EASE
- **PROCEDURE:** Tailored exercise
- **OTHER:** Continued Care and Active Monitoring
- **BEHAVIORAL:** Cognitive Behavioral Therapy (CBT)
- **PROCEDURE:** Spinal Manipulation Therapy (SMT)
- **PROCEDURE:** Yoga

## Key facts

- **NCT ID:** NCT04142177
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-06-13
- **Primary completion:** 2027-06-30
- **Final completion:** 2027-06-30
- **Target enrollment:** 2529 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04142177

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04142177, "Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT04142177. Licensed CC0.

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