# Sequential Nephron Blockade in Acute Heart Failure

> **NCT04163588** · PHASE3 · UNKNOWN · sponsor: **Policlinico Casilino ASL RMB** · enrollment: 310 (estimated)

## Conditions studied

- Acute Heart Failure

## Interventions

- **DRUG:** Metolazone
- **DRUG:** Loop Diuretics

## Key facts

- **NCT ID:** NCT04163588
- **Lead sponsor:** Policlinico Casilino ASL RMB
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2019-10-01
- **Primary completion:** 2020-10-31
- **Final completion:** 2020-12-31
- **Target enrollment:** 310 (ESTIMATED)
- **Last updated:** 2019-11-19

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04163588

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04163588, "Sequential Nephron Blockade in Acute Heart Failure". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT04163588. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*