Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

NCT04166318 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

252

Enrollment

NETWORK

Sponsor class

Conditions

Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Anal Canal Squamous Cell Carcinoma
Anal Margin Squamous Cell Carcinoma
Stage I Anal Cancer AJCC v8
Stage IIA Anal Cancer AJCC v8

Interventions

PROCEDURE: Biopsy
PROCEDURE: Biospecimen Collection
DRUG: Capecitabine
PROCEDURE: Computed Tomography
OTHER: Fludeoxyglucose F-18
DRUG: Fluorouracil
RADIATION: Intensity-Modulated Radiation Therapy
PROCEDURE: Magnetic Resonance Imaging
DRUG: Mitomycin
PROCEDURE: Positron Emission Tomography
OTHER: Quality-of-Life Assessment
OTHER: Questionnaire Administration

Sponsor

ECOG-ACRIN Cancer Research Group

Collaborators

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