# Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

> **NCT04175912** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 40 (actual)

## Conditions studied

- Metastatic Cholangiocarcinoma
- Metastatic Hepatocellular Carcinoma
- Stage III Hepatocellular Carcinoma AJCC v8
- Stage III Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IIIA Hepatocellular Carcinoma AJCC v8
- Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IIIB Hepatocellular Carcinoma AJCC v8
- Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IV Hepatocellular Carcinoma AJCC v8
- Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IVA Hepatocellular Carcinoma AJCC v8
- Stage IVB Hepatocellular Carcinoma AJCC v8
- Unresectable Cholangiocarcinoma
- Unresectable Hepatocellular Carcinoma
- Unresectable Intrahepatic Cholangiocarcinoma

## Interventions

- **DRUG:** Carboplatin
- **DRUG:** Paclitaxel
- **DRUG:** Pevonedistat

## Key facts

- **NCT ID:** NCT04175912
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-03-16
- **Primary completion:** 2023-11-27
- **Final completion:** 2026-10-31
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2025-11-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04175912

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04175912, "Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04175912. Licensed CC0.

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