# Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

> **NCT04179981** · NA · RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 668 (estimated)

## Conditions studied

- Sleep Apnea Syndrome
- Obstructive Sleep Apnea
- COPD
- Overlap Syndrome
- Quality of Life
- Neurocognitive Function
- Sleepiness
- Elderly
- Positive Airway Pressure

## Interventions

- **DEVICE:** Positive airway pressure
- **OTHER:** Conservative care (control arm)

## Key facts

- **NCT ID:** NCT04179981
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-12-01
- **Primary completion:** 2026-03-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 668 (ESTIMATED)
- **Last updated:** 2025-09-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04179981

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04179981, "Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT04179981. Licensed CC0.

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