# GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

> **NCT04192981** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **Memorial Sloan Kettering Cancer Center** · enrollment: 21 (actual)

## Conditions studied

- Brain Metastases
- Leptomeningeal Metastasis

## Interventions

- **DRUG:** GDC-0084
- **RADIATION:** whole brain radiation therapy radiation

## Key facts

- **NCT ID:** NCT04192981
- **Lead sponsor:** Memorial Sloan Kettering Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-12-06
- **Primary completion:** 2026-12
- **Final completion:** 2026-12
- **Target enrollment:** 21 (ACTUAL)
- **Last updated:** 2026-04-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04192981

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04192981, "GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04192981. Licensed CC0.

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