# A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

> **NCT04195399** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 31 (actual)

## Conditions studied

- Desmoid Fibromatosis
- Recurrent Desmoid Fibromatosis
- Unresectable Desmoid Fibromatosis

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Nirogacestat
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration
- **PROCEDURE:** X-Ray Imaging

## Key facts

- **NCT ID:** NCT04195399
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-10-07
- **Primary completion:** 2026-03-31
- **Final completion:** 2027-04-10
- **Target enrollment:** 31 (ACTUAL)
- **Last updated:** 2026-04-15

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04195399

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04195399, "A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT04195399. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*