# Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

> **NCT04195633** · PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 60 (estimated)

## Conditions studied

- Acute Leukemia
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Adult Diffuse Large Cell Lymphoma
- Anaplastic Large Cell Lymphoma
- Burkitt Lymphoma
- Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Chronic Myelomonocytic Leukemia
- Hodgkin Lymphoma
- Lymphoblastic Lymphoma
- Lymphoplasmacytic Lymphoma
- Mantle Cell Lymphoma
- Mixed Phenotype Acute Leukemia
- Myelodysplastic Syndrome
- Prolymphocytic Leukemia
- Refractory Chronic Lymphocytic Leukemia
- Refractory Follicular Lymphoma
- Refractory Marginal Zone Lymphoma
- Refractory Small Lymphocytic Lymphoma

## Interventions

- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Cyclophosphamide
- **DRUG:** Cyclosporine
- **BIOLOGICAL:** Filgrastim
- **DRUG:** Fludarabine
- **DRUG:** Mycophenolate Mofetil
- **DRUG:** Mycophenolate Sodium
- **RADIATION:** Total-Body Irradiation
- **DRUG:** Treosulfan
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT04195633
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-01-25
- **Primary completion:** 2027-04-15
- **Final completion:** 2029-03-12
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2026-02-27

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04195633

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04195633, "Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04195633. Licensed CC0.

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