# A Study With [18F]MNI-1054 to Determine Lysine -Specific Demethylase 1A (LSD1) Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Participants

> **NCT04202497** · PHASE1 · TERMINATED · sponsor: **Takeda** · enrollment: 7 (actual)

## Conditions studied

- Healthy Volunteers

## Interventions

- **DRUG:** TAK-418
- **DRUG:** [18F]MNI-1054 (radiotracer)

## Key facts

- **NCT ID:** NCT04202497
- **Lead sponsor:** Takeda
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-12-18
- **Primary completion:** 2020-03-05
- **Final completion:** 2020-03-19
- **Target enrollment:** 7 (ACTUAL)
- **Why stopped:** Study was prematurely terminated because of administrative reasons.
- **Last updated:** 2021-07-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04202497

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04202497, "A Study With [18F]MNI-1054 to Determine Lysine -Specific Demethylase 1A (LSD1) Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Participants". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04202497. Licensed CC0.

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