# Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)

> **NCT04209543** · PHASE3 · COMPLETED · sponsor: **Estetra** · enrollment: 1570 (actual)

## Conditions studied

- Vasomotor Symptoms
- Menopausal Symptoms

## Interventions

- **DRUG:** Estetrol
- **DRUG:** Placebo
- **DRUG:** Progesterone

## Key facts

- **NCT ID:** NCT04209543
- **Lead sponsor:** Estetra
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-12-30
- **Primary completion:** 2024-02-08
- **Final completion:** 2024-02-08
- **Target enrollment:** 1570 (ACTUAL)
- **Last updated:** 2025-01-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04209543

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04209543, "Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04209543. Licensed CC0.

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