# Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo

> **NCT04221230** · PHASE2 · COMPLETED · sponsor: **Neumora Therapeutics, Inc.** · enrollment: 204 (actual)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DRUG:** NMRA-335140
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT04221230
- **Lead sponsor:** Neumora Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-01-03
- **Primary completion:** 2022-04-08
- **Final completion:** 2022-06-23
- **Target enrollment:** 204 (ACTUAL)
- **Last updated:** 2025-05-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04221230

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04221230, "Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04221230. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*