# A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B

> **NCT04225715** · PHASE2 · COMPLETED · sponsor: **Hoffmann-La Roche** · enrollment: 281 (actual)

## Conditions studied

- Hepatitis B, Chronic

## Interventions

- **DRUG:** Nucleos(t)ide (NUC)
- **DRUG:** CpAM (RO7049389)
- **DRUG:** TLR7 (RO7020531)
- **DRUG:** siRNA (RO7445482)
- **DRUG:** PEG-IFN
- **DRUG:** PD-L1 LNA (RO7191863)

## Key facts

- **NCT ID:** NCT04225715
- **Lead sponsor:** Hoffmann-La Roche
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-07-05
- **Primary completion:** 2024-07-19
- **Final completion:** 2024-07-19
- **Target enrollment:** 281 (ACTUAL)
- **Last updated:** 2025-09-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04225715

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04225715, "A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B". Retrieved via AI Analytics 2026-07-09 from https://api.ai-analytics.org/clinical/NCT04225715. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*