# Hypofractionated LocoRegional Radiotherapy in Breast Cancer

> **NCT04228991** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Ontario Clinical Oncology Group (OCOG)** · enrollment: 588 (estimated)

## Conditions studied

- Breast Neoplasms
- Radiotherapy
- Lymphedema

## Interventions

- **RADIATION:** Locoregional radiation treatment - Conventional fractionation
- **RADIATION:** Locoregional radiation treatment - Hypofractionation

## Key facts

- **NCT ID:** NCT04228991
- **Lead sponsor:** Ontario Clinical Oncology Group (OCOG)
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-02-10
- **Primary completion:** 2028-07
- **Final completion:** 2030-12-31
- **Target enrollment:** 588 (ESTIMATED)
- **Last updated:** 2025-11-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04228991

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04228991, "Hypofractionated LocoRegional Radiotherapy in Breast Cancer". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT04228991. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*