# Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

> **NCT04231708** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Wayne State University** · enrollment: 20 (estimated)

## Conditions studied

- Opioid Use Disorder

## Interventions

- **DRUG:** Yohimbine + Hydrocortisone
- **DEVICE:** Active rTMS
- **DRUG:** Placebo
- **DEVICE:** Sham rTMS

## Key facts

- **NCT ID:** NCT04231708
- **Lead sponsor:** Wayne State University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-10
- **Primary completion:** 2028-12
- **Final completion:** 2028-12
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2025-12-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04231708

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04231708, "Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder". Retrieved via AI Analytics 2026-07-06 from https://api.ai-analytics.org/clinical/NCT04231708. Licensed CC0.

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