# Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

> **NCT04233866** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **ECOG-ACRIN Cancer Research Group** · enrollment: 176 (actual)

## Conditions studied

- Metastatic Pancreatic Adenocarcinoma
- Stage IV Pancreatic Cancer AJCC v8

## Interventions

- **DRUG:** Fluorouracil
- **DRUG:** Gemcitabine
- **DRUG:** Gemcitabine Hydrochloride
- **DRUG:** Leucovorin
- **DRUG:** Leucovorin Calcium
- **DRUG:** Liposomal Irinotecan
- **DRUG:** Nab-paclitaxel
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT04233866
- **Lead sponsor:** ECOG-ACRIN Cancer Research Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2020-08-26
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-12-31
- **Target enrollment:** 176 (ACTUAL)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04233866

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04233866, "Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04233866. Licensed CC0.

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