# Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

> **NCT04235777** · PHASE1 · RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 100 (estimated)

## Conditions studied

- Urothelial Cancer
- Bladder Cancer
- Genitourinary Cancer
- Urogenital Neoplasms
- Urogenital Cancer

## Interventions

- **RADIATION:** Stereotactic body radiation therapy (SBRT)
- **DRUG:** PDS01ADC
- **DRUG:** M7824

## Key facts

- **NCT ID:** NCT04235777
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-07-13
- **Primary completion:** 2027-12-01
- **Final completion:** 2027-12-01
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-04-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04235777

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04235777, "Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies". Retrieved via AI Analytics 2026-07-31 from https://api.ai-analytics.org/clinical/NCT04235777. Licensed CC0.

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