# Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses

> **NCT04276259** · PHASE4 · COMPLETED · sponsor: **Marta Peciña, MD PhD** · enrollment: 120 (actual)

## Conditions studied

- Major Depressive Disorder
- Depression

## Interventions

- **DRUG:** Buprenorphine
- **DRUG:** Naltrexone
- **DRUG:** Oral Placebo
- **DRUG:** IM Placebo
- **DEVICE:** Theta burst stimulation (TBS) of the ventromedial prefrontal cortex.

## Key facts

- **NCT ID:** NCT04276259
- **Lead sponsor:** Marta Peciña, MD PhD
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-10-19
- **Primary completion:** 2026-01-21
- **Final completion:** 2026-01-21
- **Target enrollment:** 120 (ACTUAL)
- **Last updated:** 2026-02-13

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04276259

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04276259, "Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04276259. Licensed CC0.

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