# Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

> **NCT04278404** · — · RECRUITING · sponsor: **Duke University** · enrollment: 5000 (estimated)

## Conditions studied

- Coronavirus Infection (COVID-19)
- Pulmonary Arterial Hypertension
- Urinary Tract Infections in Children
- Hypertension
- Pain
- Hyperphosphatemia
- Primary Hyperaldosteronism
- Edema
- Hypokalemia
- Heart Failure
- Hemophilia
- Menorrhagia
- Insomnia
- Pneumonia
- Skin Infection
- Arrythmia
- Asthma in Children
- Bronchopulmonary Dysplasia
- Adrenal Insufficiency
- Fibrinolysis; Hemorrhage
- Attention Deficit Hyperactivity Disorder
- Multisystem Inflammatory Syndrome in Children (MIS-C)
- Kawasaki Disease
- Coagulation Disorder
- Down Syndrome

## Interventions

- **DRUG:** The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:

## Key facts

- **NCT ID:** NCT04278404
- **Lead sponsor:** Duke University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2020-03-05
- **Primary completion:** 2027-03
- **Final completion:** 2027-07
- **Target enrollment:** 5000 (ESTIMATED)
- **Last updated:** 2026-04-06

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04278404

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04278404, "Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04278404. Licensed CC0.

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