# The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)

> **NCT04279522** · NA · COMPLETED · sponsor: **Neurolief Ltd.** · enrollment: 124 (actual)

## Conditions studied

- MDD

## Interventions

- **DEVICE:** Relivion®DP- Active
- **DEVICE:** Relivion®DP- Sham

## Key facts

- **NCT ID:** NCT04279522
- **Lead sponsor:** Neurolief Ltd.
- **Sponsor class:** INDUSTRY
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-08-31
- **Primary completion:** 2024-06-07
- **Final completion:** 2024-06-07
- **Target enrollment:** 124 (ACTUAL)
- **Last updated:** 2025-08-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04279522

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04279522, "The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)". Retrieved via AI Analytics 2026-07-08 from https://api.ai-analytics.org/clinical/NCT04279522. Licensed CC0.

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