# A Retrospective Cohort Study: The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma

> **NCT04283955** · — · COMPLETED · sponsor: **Sun Yat-sen University** · enrollment: 93 (actual)

## Conditions studied

- Pediatric NHL

## Interventions

- **DRUG:** High-dose MTX based chemotherapy

## Key facts

- **NCT ID:** NCT04283955
- **Lead sponsor:** Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2014-03-01
- **Primary completion:** 2019-03-01
- **Final completion:** 2019-03-01
- **Target enrollment:** 93 (ACTUAL)
- **Last updated:** 2020-02-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04283955

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04283955, "A Retrospective Cohort Study: The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04283955. Licensed CC0.

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