# Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

> **NCT04297592** · PHASE4 · ENROLLING_BY_INVITATION · sponsor: **Mayo Clinic** · enrollment: 4618 (estimated)

## Conditions studied

- Infections Joint Prosthetic
- Overweight or Obesity
- MSSA Colonization
- MRSA
- Chronic Kidney Diseases
- Diabetes
- Autoimmune Diseases
- Inflammatory Disease
- Tobacco Use

## Interventions

- **DRUG:** Cephalexin
- **DRUG:** Doxycycline
- **DRUG:** Cefadroxil

## Key facts

- **NCT ID:** NCT04297592
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ENROLLING_BY_INVITATION
- **Start date:** 2020-06-11
- **Primary completion:** 2026-06
- **Final completion:** 2026-06
- **Target enrollment:** 4618 (ESTIMATED)
- **Last updated:** 2025-07-03


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04297592

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04297592, "Antibiotic Prophylaxis in High-Risk Arthroplasty Patients". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT04297592. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*