# Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial

> **NCT04302870** · PHASE2,PHASE3 · RECRUITING · sponsor: **University of Edinburgh** · enrollment: 1150 (estimated)

## Conditions studied

- Motor Neuron Disease, Amyotrophic Lateral Sclerosis

## Interventions

- **DRUG:** Memantine Hydrochloride Oral Solution
- **DRUG:** Trazodone Hydrochloride oral solution
- **DRUG:** Placebo oral solution
- **DRUG:** Amantadine Hydrochloride Oral Solution
- **DRUG:** Tacrolimus 1Mg Cap
- **DRUG:** Placebo capsule

## Key facts

- **NCT ID:** NCT04302870
- **Lead sponsor:** University of Edinburgh
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-02-27
- **Primary completion:** 2030-12
- **Final completion:** 2030-12
- **Target enrollment:** 1150 (ESTIMATED)
- **Last updated:** 2026-03-04

## Collaborators

- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04302870

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04302870, "Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT04302870. Licensed CC0.

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