# A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

> **NCT04322318** · PHASE2 · RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 256 (estimated)

## Conditions studied

- Anaplastic Kidney Wilms Tumor
- Recurrent Kidney Wilms Tumor
- Stage II Kidney Wilms Tumor
- Stage III Kidney Wilms Tumor
- Stage IV Kidney Wilms Tumor

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Scan
- **DRUG:** Carboplatin
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin
- **DRUG:** Etoposide
- **DRUG:** Ifosfamide
- **DRUG:** Irinotecan
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography
- **RADIATION:** Radiation Therapy
- **PROCEDURE:** Surgical Procedure
- **DRUG:** Topotecan
- **PROCEDURE:** Transabdominal Ultrasound
- **DRUG:** Vincristine
- **PROCEDURE:** X-Ray Imaging

## Key facts

- **NCT ID:** NCT04322318
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-10-19
- **Primary completion:** 2027-07-01
- **Final completion:** 2027-07-01
- **Target enrollment:** 256 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04322318

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04322318, "A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT04322318. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*