# Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer

> **NCT04329065** · PHASE2 · RECRUITING · sponsor: **University of Washington** · enrollment: 25 (estimated)

## Conditions studied

- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine
- **DRUG:** Paclitaxel
- **BIOLOGICAL:** Trastuzumab
- **BIOLOGICAL:** Pertuzumab
- **DRUG:** Docetaxel
- **DRUG:** Carboplatin
- **PROCEDURE:** Ultrasound Imaging
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT04329065
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-04-20
- **Primary completion:** 2026-08-15
- **Final completion:** 2027-08-15
- **Target enrollment:** 25 (ESTIMATED)
- **Last updated:** 2025-11-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04329065

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04329065, "Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT04329065. Licensed CC0.

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