# Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin

> **NCT04330677** · PHASE1 · COMPLETED · sponsor: **University Hospital, Bonn** · enrollment: 487 (actual)

## Conditions studied

- Oxytocin
- Estrogen
- Fear Extinction
- Emotion Processing
- Memory

## Interventions

- **DRUG:** Oxytocin nasal spray
- **DRUG:** Placebo nasal spray
- **DRUG:** Estrogen Gel
- **DRUG:** Placebo Gel

## Key facts

- **NCT ID:** NCT04330677
- **Lead sponsor:** University Hospital, Bonn
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2016-09-18
- **Primary completion:** 2020-01-25
- **Final completion:** 2020-01-25
- **Target enrollment:** 487 (ACTUAL)
- **Last updated:** 2020-04-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04330677

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04330677, "Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT04330677. Licensed CC0.

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