Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation
Conditions
- Acute Leukemia
- Hematologic and Lymphocytic Disorder
- Myelodysplastic Syndrome
- Primary Myelofibrosis
- Secondary Myelofibrosis
Interventions
- DRUG: Fludarabine
- DRUG: Itacitinib Adipate
- DRUG: Melphalan
- OTHER: Quality-of-Life Assessment
- OTHER: Questionnaire Administration
- DRUG: Sirolimus
- DRUG: Tacrolimus
Sponsor
City of Hope Medical Center
Collaborators