Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

NCT04339777 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

66

Enrollment

NIH

Sponsor class

Conditions

Lymphoproliferative Disorders
Autoimmune Lymphoproliferative
Immune System Diseases
Common Variable Immunodeficiency
Primary T-cell Immunodeficiency Disorders

Interventions

DRUG: Busulfan test dose
DRUG: Fludarabine
DRUG: Busulfan
DRUG: Alemtuzumab
RADIATION: Total body Irradiation
PROCEDURE: Allogeneic HSCT
DRUG: Tacrolimus (Tacro)
DRUG: Mycophenolate mofetil (MMF)
DRUG: Cyclophosphamide (Cytoxan)

Sponsor

National Cancer Institute (NCI)