# The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial

> **NCT04343326** · PHASE2,PHASE3 · UNKNOWN · sponsor: **Shahid Beheshti University of Medical Sciences** · enrollment: 30 (estimated)

## Conditions studied

- Keratoconus

## Interventions

- **PROCEDURE:** perform corneal collagen cross linking accelerated and delivery of systemic oxygen
- **PROCEDURE:** perform corneal collagen cross linking accelerated and without additional oxygen therapy
- **PROCEDURE:** perform Conventiona corneal collagen cross linking

## Key facts

- **NCT ID:** NCT04343326
- **Lead sponsor:** Shahid Beheshti University of Medical Sciences
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2020-01-01
- **Primary completion:** 2020-05-01
- **Final completion:** 2020-06-01
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2020-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04343326

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04343326, "The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT04343326. Licensed CC0.

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