# Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

> **NCT04343573** · PHASE2 · COMPLETED · sponsor: **Memorial Sloan Kettering Cancer Center** · enrollment: 102 (actual)

## Conditions studied

- Leptomeningeal Metastases

## Interventions

- **RADIATION:** Involved-field Photon Radiation Therapy
- **RADIATION:** Proton Craniospinal Irradiation (CSI)
- **OTHER:** Neurocognitive Assessment
- **OTHER:** MDASI-BT and MDASI-SP

## Key facts

- **NCT ID:** NCT04343573
- **Lead sponsor:** Memorial Sloan Kettering Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-04-10
- **Primary completion:** 2026-02-25
- **Final completion:** 2026-02-25
- **Target enrollment:** 102 (ACTUAL)
- **Last updated:** 2026-02-27

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04343573

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04343573, "Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors". Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/clinical/NCT04343573. Licensed CC0.

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