# Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse

> **NCT04351113** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Joel Trinity** · enrollment: 82 (actual)

## Conditions studied

- Aging
- Oxidative Stress
- Vascular Endothelium
- Skeletal Muscle
- Antioxidants

## Interventions

- **DIETARY_SUPPLEMENT:** MITO-AO
- **DIETARY_SUPPLEMENT:** PB-125
- **OTHER:** Placebo
- **OTHER:** Passive Leg Movement (PLM)
- **OTHER:** Plantar flexion
- **OTHER:** Isometric knee extensor test
- **OTHER:** Bed rest

## Key facts

- **NCT ID:** NCT04351113
- **Lead sponsor:** Joel Trinity
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-09-01
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-06-30
- **Target enrollment:** 82 (ACTUAL)
- **Last updated:** 2026-04-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04351113

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04351113, "Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT04351113. Licensed CC0.

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