# Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome

> **NCT04364750** · EARLY_PHASE1 · COMPLETED · sponsor: **McMaster University** · enrollment: 30 (actual)

## Conditions studied

- Irritable Bowel Syndrome

## Interventions

- **DIETARY_SUPPLEMENT:** L-Histidine
- **DIETARY_SUPPLEMENT:** High-FODMAP beverage
- **DIETARY_SUPPLEMENT:** Low-FODMAP beverage
- **DIETARY_SUPPLEMENT:** Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2.
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT04364750
- **Lead sponsor:** McMaster University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2021-07-15
- **Primary completion:** 2026-02-10
- **Final completion:** 2026-02-10
- **Target enrollment:** 30 (ACTUAL)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT04364750

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT04364750, "Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT04364750. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*