Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

Conditions

• Primary Myelofibrosis
• Secondary Myelofibrosis

Interventions

• DRUG: Cyclophosphamide
• DRUG: JAK Inhibitor
• DRUG: Fludarabine
• BIOLOGICAL: Recombinant Granulocyte Colony-Stimulating Factor
• DRUG: Melphalan
• DRUG: Mycophenolate Mofetil
• PROCEDURE: Peripheral Blood Stem Cell Transplantation
• DRUG: Tacrolimus
• RADIATION: Total-Body Irradiation
• PROCEDURE: Computed Tomography
• PROCEDURE: Magnetic Resonance Imaging
• PROCEDURE: Bone Marrow Biopsy
• PROCEDURE: Bone Marrow Aspiration
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Echocardiography Test
• PROCEDURE: Multigated Acquisition Scan

Sponsor

Fred Hutchinson Cancer Center