CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia
Conditions
- Recurrent Acute Myeloid Leukemia
- Recurrent Chronic Myelomonocytic Leukemia
- Recurrent Myelodysplastic Syndrome
- Refractory Acute Myeloid Leukemia
- Refractory Chronic Myelomonocytic Leukemia
- Refractory Mixed Phenotype Acute Leukemia
- Refractory Myelodysplastic Syndrome
- Refractory Acute Leukemia of Ambiguous Lineage
- Refractory Acute Undifferentiated Leukemia
Interventions
- DRUG: Cladribine
- DRUG: Cyclophosphamide
- DRUG: Cyclosporine
- DRUG: Cytarabine
- BIOLOGICAL: Filgrastim
- PROCEDURE: Hematopoietic Cell Transplantation
- DRUG: Mitoxantrone
- DRUG: Mycophenolate Mofetil
- DRUG: Mycophenolate Sodium
- RADIATION: Total-Body Irradiation
- DRUG: Idarubicin
- DRUG: Fludarabine
- DRUG: Cytarabine
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Echocardiography Test
- PROCEDURE: X-Ray Imaging
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Bone Marrow Aspiration
- PROCEDURE: Biospecimen Collection
Sponsor
Fred Hutchinson Cancer Center
Collaborators